PBX1 Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Peptide ELISA: Detection Limit: 1/32000. Western blot: 0.5-1.5 µg/ml. Detects a band of Approx 45kDa in lysates of cell line K562.
Reactivity	Canine, Human, Mouse, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide from the internal region of the protein sequence according to NP_002576.1.
Formulation	Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer State: Aff - Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	PBX homeobox 1
Database Link	Entrez Gene 5087 Human UniProt ID P40424
Background	This nonactivating protein which could be a repressor; binds the sequence 5'-ATCAATCAA-3'. It is converted into a potent transcriptional activator by the (1;19) translocation. PBX1 May have a role in steroidogenesis and subsequently sexual development and differentiation, and is expressed in all tissues except in cells of the B and T lineage. PBX1 is involved in a form of pre-B-cell acute lymphoblastic leukemia (B-ALL) (25% of human pediatric cases) through a chromosomal translocation t(1;19)(q23;p13.3) which involves PBX1 and E2A genes. E2A-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family. PBX1 belongs to the TALE/PBX homeobox family, and contains 1 homeobox domain.
Synonyms	Homeobox protein PBX1, Homeobox protein PRL
Note	Calculated Molecular Weight: 46.6kDa according to NP_002576.1
Reference Data

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