MEIS1 Rabbit Polyclonal Antibody
CAT#: AP20611PU-N
MEIS1 rabbit polyclonal antibody, Aff - Purified
Need it in bulk or conjugated?
Get a free quote
CNY 4,640.00
货期*
2周
规格
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | Western blot: 1/500 - 1/1000. |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | This antibody detects endogenous levels of Meis1 protein. (region surrounding Ile278) |
Formulation | Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide |
Concentration | 1.0 mg/ml |
Purification | Affinity chromatography (> 95% (by SDS-PAGE) |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Predicted Protein Size | ~ 37 kDa |
Gene Name | Meis homeobox 1 |
Database Link | |
Background | Hox, Pbx, and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Hox proteins are involved in regulating tissue patterning during development, and they are also expressed n lineage- and stage-specific patterns during adult ematopoietic ifferentiation and in leukemias. The Hox proteins, which include paralog groups 1 to 10, have a low intrinsic binding affinity for DNA and are instead associated into cooperative DNA binding complexes with Pbx or the Pbx related Meis proteins, which result in an enhanced Hox-DNA binding affinity and an increased selectivity for the binding site. Both Meis1 and 2 (also known as Meis-related gene 1) are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. In addition to binding with Hox proteins, Meis1 also forms heterodimers with the ubiquitously expressed Pbx proteins, including Pbx1, Pbx2 and Pbx3, and these complexes contain distinct DNA-binding specificities. |
Synonyms | Homeobox protein Meis1 |
Reference Data | |
Protein Families | Transcription Factors |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...