Thrombin Receptor (F2R) Rabbit Polyclonal Antibody

CAT#: AP21049PU-S

Thrombin Receptor (F2R) rabbit polyclonal antibody, Aff - Purified



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CNY 800.00


货期*
2周

规格
    • 25 ul

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Specifications

Product Data
Applications WB
Recommend Dilution Western blot: 1/500 - 1/1000.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of Thrombin R protein.
(region surrounding Ser42)
Formulation Phosphate buffered saline (PBS), pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 15 mM sodium azide
Concentration 1.0 mg/ml
Purification Affinity chromatography (> 95% (by SDS-PAGE)
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Predicted Protein Size ~ 48 kDa
Gene Name coagulation factor II thrombin receptor
Background Thrombin is a serine protease that is involved in platelet aggregation and blood coagulation. It is cleaved from its precursor, prothrombin, and converts fibrinogen to fibrin in the final step of the clotting cascade. Thrombin mediates its regulatory effects by activating cell surface receptors. These receptors, including thrombin receptor (also designated PAR-1, for protease-activated receptor-1), PAR-2 and PAR-3 are members of the G-protein coupled receptor family, and share a similiar gene structure. Thrombin cleaves its receptor, releasing a 41 amino acid peptide which acts as a platelet agonist.
Upon this activation by thrombin, the thrombin receptors trigger an increase in cytosolic Ca2+ concentration. Unactivated thrombin receptor cycles between the cell surface and an intracellular pool, while activated receptor internalizes rapidly and is degraded in the lysosomes. The human thrombin receptor is also known to be regulated by Sp1 and Sp3 transcription factors.
Synonyms Proteinase-activated receptor 1, PAR-1, PAR1, CF2R
Reference Data
Protein Families Druggable Genome, GPCR, Transmembrane
Protein Pathways Calcium signaling pathway, Complement and coagulation cascades, Endocytosis, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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