anoctamin 5 (ANO5) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1/1,000. Western blotting: 1/100-1/500.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide -KLH conjugated between 798~828 amino acids from the C-terminal region of Human ANO5.
Specificity	Recognizes ANO5 (C-term).
Formulation	PBS with 0.09% (W/V) Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A Chromatography followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	anoctamin 5
Database Link	Entrez Gene 233246 MouseEntrez Gene 203859 Human UniProt ID Q75V66
Background	ANO5 is a member of the anoctamin family of transmembrane proteins. This protein is likely a calcium activated chloride channel. Defects in ANO5 are the cause of gnathodiaphyseal dysplasia (GDD), also known as osteogenesis imperfecta with unusual skeletal lesions or gnathodiaphyseal sclerosis. GDD is a rare skeletal syndrome characterized by bone fragility, sclerosis of tubular bones, and cemento-osseous lesions of the jawbone. Patients experience frequent bone fractures caused by trivial accidents in childhood; however the fractures heal normally without bone deformity. The jaw lesions replace the tooth-bearing segments of the maxilla and mandible with fibrous connective tissues, including various amounts of cementum-like calcified mass, sometimes causing facial deformities. Patients also have a propensity for jaw infection and often suffer from purulent osteomyelitis-like symptoms, such as swelling of and pus discharge from the gums, mobility of the teeth, insufficient healing after tooth extraction and exposure of the lesions into the oral cavity.
Synonyms	GDD1, TMEM16E, Gnathodiaphyseal dysplasia 1 protein, Transmembrane protein 16E
Note	Calculated Molecular Weight: 107188 Da
Reference Data
Protein Families	Transmembrane

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