ROBO1 (994-1006) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/8000. Immunohistochemistry on Paraffin Sections: 2 µg/ml. Western Blot: 1 - 3 µg/ml.
Reactivity	Canine, Equine, Hamster, Human, Monkey, Mouse, Porcine, Rat, Bovine, Bat, Chicken, Xenopus
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from an internal region of human ROBO1
Specificity	This antibody detects ROBO1 at aa 994-1006. It is expected to recognise all reported isoforms (NP_002932.1; NP_598334.1; NP_001139316.1; NP_001139317.1).
Formulation	Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Immunoaffinity chromatography
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	roundabout guidance receptor 1
Database Link	Entrez Gene 19876 MouseEntrez Gene 58946 RatEntrez Gene 6091 Human UniProt ID Q9Y6N7
Background	Robo proteins are highly conserved transmembrane receptors that are expressed by growing axon tips. They play multiple parts in guiding axons to their correct locations in the developing brain and are particularly important for enabling axons to cross the midline. In all mammalian species studied so far, Robo is the receptor for Slit, a protein secreted by the midline of the nervous system. When bound to each other, Split and Robo act as a chemorepellent, inducing growth of axon tips away from the midline.
Synonyms	ROBO-1, Roundabout homolog 1, DUTT1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Axon guidance

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