PCK1 (513-524) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	ELISA: 1/8000. Immunohistochemistry on Paraffin Sections: 2 µg/ml.
Reactivity	Canine, Human, Mouse, Rat, Bat, Equine, Monkey, Rabbit
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from an internal region of human PCK1
Specificity	This antibody detects PCK1 / PEPCK1 at aa 513-524.
Formulation	Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Immunoaffinity chromatography
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	phosphoenolpyruvate carboxykinase 1
Database Link	Entrez Gene 18534 MouseEntrez Gene 362282 RatEntrez Gene 696207 MonkeyEntrez Gene 5105 Human UniProt ID P35558
Background	PCK1 is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency.
Synonyms	PEPCK-C, PEPCKC, Phosphoenolpyruvate carboxylase, PEP carboxykinase
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Adipocytokine signaling pathway, Citrate cycle (TCA cycle), Glycolysis / Gluconeogenesis, Insulin signaling pathway, Metabolic pathways, PPAR signaling pathway, Pyruvate metabolism

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.