GABA A Receptor alpha 4 (GABRA4) (349-361) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/16000. Immunohistochemistry on Paraffin Sections: 2.5 µg/ml. Western Blot: 0.1 - 0.3 µg/ml.
Reactivity	Bovine, Human
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from an internal region of human GABRA4 (NP_000800.2)
Specificity	This antibody detects GABRA4 (Internal).
Formulation	Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Immunoaffinity chromatography
Conjugation	Unconjugated
Storage Condition	Store (in aliquots) at -20 °C. Dilute only prior to immediate use. Avoid repeated freezing and thawing.
Gene Name	gamma-aminobutyric acid type A receptor alpha4 subunit
Database Link	Entrez Gene 2557 Human UniProt ID P48169
Background	Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A receptor subtype. GABA-A receptors are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A receptor is a multimeric subunit complex. To date six alpha, four beta, and four gamma subunits, plus alternative splicing variants of some of these subunits, have been identified. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor.
Synonyms	GABRA-4, GABAA Receptor alpha-4
Reference Data
Protein Families	Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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