Calcium Sensing Receptor (CASR) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 15 µg/ml. Western Blot: 1 - 2 µg/ml.
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	CASR antibody was raised against a synthetic peptide from N-terminal of rat calcium sensing receptor
Specificity	This antibody reacts to Calcium-Sensing Receptor CASR (CASR).
Formulation	10 mM PBS, pH 7.4 containing BSA, sodium azide. State: Purified State: Liquid purified Ig fraction
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	calcium sensing receptor
Database Link	Entrez Gene 24247 RatEntrez Gene 846 Human UniProt ID P41180
Background	CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis. This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism. On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia. Hjalm et al. (2001) and Awata et al. (2001) have identified the binding of filamin-1 to the C-terminal tail of CASR, which may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CASR-mediated activation of MAPK. Multiple isoforms for CASR are produced by alternative splicing.
Synonyms	Extracellular calcium-sensing receptor, GPRC2A, PCAR1
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane

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