Bak (BAK1) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 1/300.
Reactivity	Hamster, Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from N-terminal of Human Bcl-2-like 7.
Specificity	This antibody recognizes BCL2-antagonist/killer 1 (BAK1).
Formulation	10mM PBS, pH 7.4 State: Purified State: Liquid purified Ig fraction Stabilizer: 1% BSA Preservative: 0.09% Sodium Azide
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	BCL2 antagonist/killer 1
Database Link	Entrez Gene 12018 MouseEntrez Gene 578 Human UniProt ID Q16611
Background	Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bak, a pro-apoptotic Bcl-2 family member, is an oligomeric protein that localizes to the mitochondria. It is thought to share significant functional homology with Bax, another pro-apoptotic Bcl-2 family member, as disruption of bak or bax has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking bak and bax show decreased apoptotic capability.
Synonyms	BAK1, BAK, BCL2L7, Bcl2-L-7, CDN1
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transmembrane

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