Nicotinic Acetylcholine Receptor alpha 7 (CHRNA7) (Internal) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	ELISA. Immunohistochemistry on Paraffin Sections: 3 - 6 µg/ml.
Reactivity	Human, Bovine, Canine, Chicken, Equine, Monkey, Porcine
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from an internal region of human CHRNA7 (NP_000737.1)
Specificity	This antibody reacts to Cholinergic Receptor, Nicotinic, Alpha Polypeptide 7 (CHRNA7). It also reacts with CHRNA7-FAM7A fusion isoform 1 (NP_647536.1) and isoform 2 (NP_683709.1).
Formulation	Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cholinergic receptor nicotinic alpha 7 subunit
Database Link	Entrez Gene 1139 Human UniProt ID P36544
Background	The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.
Synonyms	Nicotinic acetylcholine receptor subunit alpha-7, CHRNA7, NACHRA7
Reference Data
Protein Families	Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
Protein Pathways	Calcium signaling pathway

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.