SPI1 (27-37) Goat Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
Reactivity	Human, Bovine, Canine, Equine, Porcine, Rabbit
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from an internal region of human SPI1 / PU.1 (NP_001074016.1; NP_003111.2)
Specificity	This antibody reacts to the internal region of Spi-1 Proto-oncogene (SPI1).
Formulation	Tris saline buffer, pH 7.3 containing 0.5% BSA and 0.02% sodium azide State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	Spi-1 proto-oncogene
Database Link	Entrez Gene 6688 Human UniProt ID P17947
Background	Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.
Synonyms	Transcription factor PU.1, SPI-1 proto-oncogene, SFPI1
Reference Data
Protein Families	Transcription Factors
Protein Pathways	Acute myeloid leukemia, Pathways in cancer

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