TXNRD1 (600-612) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/32000. Immunohistochemistry on Paraffin Sections: 2.5 µg/ml. Western Blot: 1/32000, 0.1 - 1 µg/ml.
Reactivity	Human, Canine, Monkey, Porcine
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from C-terminus of human TXNRD1
Specificity	This antibody detects Thioredoxin reductase 1 (TXNRD1) (C-term). It is expected to recognise reported isoform 1 (NP_003321.2), isoform 2 (NP_877393.1; NP_877419.1; NP_877420.1) and isoform 3 (NP_001087240.1).
Formulation	Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	thioredoxin reductase 1
Database Link	Entrez Gene 7296 Human UniProt ID Q16881
Background	TRXR1 / TXNRD1 is a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination.
Synonyms	KDRF, GRIM-12
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Pyrimidine metabolism

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