FOXA2 (453-463) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/2000. Immunohistochemistry on Paraffin Sections: 3.75 µg/ml. Western Blot: 1-3 µg/ml.
Reactivity	Human, Bovine, Bat, Canine, Chicken, Equine, Hamster, Monkey, Mouse, Porcine, Rabbit, Rat, Xenopus
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from C-terminus of human FOXA2
Specificity	This antibody detects FOXA2 / HNF3B (C-term). This antibody is expected to recognize both reported isoforms.
Formulation	Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	forkhead box A2
Database Link	Entrez Gene 15376 MouseEntrez Gene 25099 RatEntrez Gene 3170 Human UniProt ID Q9Y261
Background	Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity).
Synonyms	HNF-3-beta, HNF-3B, TCF3B
Reference Data
Protein Families	Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors
Protein Pathways	Maturity onset diabetes of the young

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