PDE4 (PDE4B) (723-736) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/8000. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 1/8000, 0.5 - 1 µg/ml.
Reactivity	Human, Mouse
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from C-terminus of Human PDE4B
Specificity	This antibody detects PDE4B (C-term) and is expected to recognize all reported isoforms.
Formulation	Tris saline buffer, pH~7.3 containing 0.5% BSA as stabilizer and 0.02% Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	phosphodiesterase 4B
Database Link	Entrez Gene 18578 MouseEntrez Gene 5142 Human UniProt ID Q07343
Background	Phosphodiesterase 4B, a cAMP-specific phosphodiesterase, regulates pro-inflammatory and immune cells, and may function in learning, leukemia, memory (or other brain functions), and penile erectile dysfunction. PDE4B activity is inhibited by rolipram. At least three PDE4B isoforms, produced by alternative splicing, have been reported.
Synonyms	PDE4B, DPDE4, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, EC=3.1.4.17, PDE32
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Progesterone-mediated oocyte maturation, Purine metabolism

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