Growth Hormone (GH1) (1-217) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot: 1/500 - 1/3000.
Reactivity	Human, Monkey
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 217 of Human Growth hormone
Specificity	This antibody detects GH1 at aa 1-217.
Formulation	0.1 M Tris-glycine, pH 7, 10% Glycerol, 0.01% Thimerosal State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store (in aliquots) at -20 °C. Dilute only prior to immediate use. Avoid repeated freezing and thawing.
Gene Name	growth hormone 1
Database Link	Entrez Gene 2688 Human UniProt ID P01241
Background	The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
Synonyms	Pituitary growth hormone, Growth hormone 1, HGH
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Neuroactive ligand-receptor interaction

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