VRL1 (TRPV2) (595-764) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot: 1/500 - 1/3000.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein fragment containing a sequence corresponding to a region within amino acids 595 and 764 of VRL1
Specificity	This antibody detects TRPV2 / Vanilloid receptor-like protein 1 at aa 595-764.
Formulation	0.1 M Tris-glycine, pH 7, 10% Glycerol containing 0.01% Thimerosal as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody in aliquots at -20°C. Avoid repeated freezing and thawing.
Gene Name	transient receptor potential cation channel subfamily V member 2
Database Link	Entrez Gene 22368 MouseEntrez Gene 51393 Human UniProt ID Q9Y5S1
Background	Transient Receptor Potential Vanilloid (TRPV) channels are widely expressed in both sensory and nonsensory cells. TRPV2, a member of transient receptor potential ion channels, responds to high-threshold noxious heat (with a threshold of approximately 52 degrees C), but neither to capsaicin nor to proton. TRPV2 transcripts are not restricted to the sensory nervous system, indicating that this channel may be activated by stimuli other than heat. It has been proposed that responses to noxious heat involve these related, but distinct, ion-channel subtypes that together detect a range of stimulus intensities.
Synonyms	VRL, OTRPC2, Vanilloid receptor-like protein 1, VRL-1
Reference Data
Protein Families	Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane

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