EAAT1 (SLC1A3) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: At 0.5-1μg/ml with the appropriate system to detect glast in cells and tissues.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a sequence at the C-terminal of the human Glast
Specificity	This antibody detects SLC1A3 / EAAT1 at C-term.
Formulation	5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3 State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	0.2ml of distilled water will yield a concentration of 500μg/ml.
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	solute carrier family 1 member 3
Database Link	Entrez Gene 20512 MouseEntrez Gene 29483 RatEntrez Gene 6507 Human UniProt ID P43003
Background	Glast, also known as EAAT1. EAAT1 (SLC1A3) is a member of a family of high-affinity sodium-dependent transporter molecules that regulate neurotransmitter concentrations at the excitatory glutamatergic synapses of the mammalian central nervous system. human GLAST1 gene contains 10 exons spanning at least 85 kb. EAAT1 gene is mapped to chromosome 5p13. GLAST is required for normal signal transmission between photoreceptors and bipolar cells and that both GLAST and GLT-1 play a neuroprotective role during ischemia in the retina. Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures.
Synonyms	GLAST, GLAST1, GLAST-1
Reference Data
Protein Families	Transmembrane

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