COX2 (PTGS2) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 0.1-0.5 μg/ml. Immunohistochemistry on Paraffin Sections: 1-2 μg/ml by heat antigen treatement.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminal of Human COX-2
Specificity	This antibody detects Cyclooxygenase 2 (N-term). No cross reactivity with other proteins.
Formulation	0.2mg Na2HPO4, 0.9mg NaCl State: Aff - Purified State: Lyophilized Ig fraction Stabilizer: 5mg BSA Preservative: 0.05mg Sodium Azide,  0.05 mg Thimerosal
Reconstitution Method	Restore with 0.2 ml distilled water to a concentration of 500 μg/ml
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	prostaglandin-endoperoxide synthase 2
Database Link	Entrez Gene 19225 MouseEntrez Gene 29527 RatEntrez Gene 5743 Human UniProt ID P35354
Background	Cyclooxygenase (Cox) is the key enzyme in conversion of arachidonic acid to PGs, and two isoforms,Cox-1 and Cox-2, have been identified. Cox-2 gene encodes an inducible prostaglandin synthase enzyme that is overexpressed in adenocarcinomas and other tumors. Deletion of the murine Cox-2 gene in Min mice reduced the incidence of intestinal tumors, suggesting that it is required for tumorigenesis. This gene is localized to sites associated with retinal blood vessels, and plays an important role in blood vessel formation in the retina. And the glucocorticoid receptor suppression of COX-2 is also crucial for curtailing lethal immune activation, and suggest new therapeutic approaches for regulation of T-cell-mediated inflammatory diseases.
Synonyms	Cyclooxygenase-2, PTGS2, COX2, PHS II, PGH synthase 2, PGHS-2, PGHS2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Arachidonic acid metabolism, Pathways in cancer, Small cell lung cancer, VEGF signaling pathway

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