TIMP4 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: At 1-2μg/ml with the appropriate system to detect TIMP-4 in cells and tissues.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A peptide mapping at the C-terminal end of human TIMP-4
Specificity	This antibody detects TIMP4 (C-term). No cross reactivity with other proteins.
Formulation	50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4 State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	1.2% sodium acetate or neutral PBS. If 0.5ml of PBS is used, the antibody concentration will be 100μg/ml.
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	TIMP metallopeptidase inhibitor 4
Database Link	Entrez Gene 110595 MouseEntrez Gene 680130 RatEntrez Gene 7079 Human UniProt ID Q99727
Background	The tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. TIMP4 gene contains 5 exons that span 6 kb of genomic DNA.The gene is expressed as a 1.4-kb transcript abundant in heart and present at low levels in several other tissues. expressed TIMP4 inhibits MMPs in vitro. TIMP4 gene is mapped to chromosome 3p25. TIMP-4 binds both progelatinase A and the C domain in a similar manner to that of TIMP-2.
Synonyms	TIMP-4, Tissue inhibitor of metalloproteinases 4, Metalloproteinase inhibitor 4
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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