Caspase 2 (CASP2) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: Use 1 μg/ml with the appropriate system to detect Caspase 2 in cells and tissues. Immunohistochemistry on Paraffin Sections: A previous lot of this antibody has been used at 1-2 μg/ml to detect Caspase 2 in formalin fixed and paraffin embedded tissues.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide mapping at the C-terminal of Human Caspase 2
Specificity	This antibody detects Caspase-2 (C-term). No cross reactivity with other proteins.
Formulation	0.9 mg NaCl, 0.2 mg Na2HPO4 State: Aff - Purified State: Lyophilized purified Ig fraction Stabilizer: 5 mg BSA Preservative: 0.05 mg Thimerosal, 0.05 mg Sodium Azide
Reconstitution Method	0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	caspase 2
Database Link	Entrez Gene 12366 MouseEntrez Gene 64314 RatEntrez Gene 835 Human UniProt ID P42575
Background	Caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Caspase-2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.
Synonyms	CASP-2, CASP2, ICH1, ICH-1 protease, NEDD2
Reference Data
Protein Families	Druggable Genome, Protease

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