Apolipoprotein A I (APOA1) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1 μg/ml.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminal of human APOA1
Specificity	This antibody detects Apolipoprotein A I (APO AI) (N-term). No cross reactivity with other proteins.
Formulation	5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05mg Thimerosal, 0.05 mg Sodium Azide State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	Restore in 0.2 ml distilled water to a concentration of 0.5 mg/ml
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	apolipoprotein A1
Database Link	Entrez Gene 11806 MouseEntrez Gene 25081 RatEntrez Gene 335 Human UniProt ID P02647
Background	Apolipoprotein A-1, also known as APOA1, is a human protein with a specific role in lipid metabolism. It binds to lipopolysaccharide or endotoxin, and has a major role in the anti-endotoxin function of HDL. The gene is mapped to 11q23. And it is a single polypeptide chain with 243 amino acid residues of known primary amino acid sequence. The ApoA-I protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I was also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.Additionally, ApoA-I overexpression promotes macrophage-specific reverse cholesterol transport.
Synonyms	APOA1, ApoA-I, Apo-AI, ApoAI
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	PPAR signaling pathway

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