DR3 (TNFRSF25) (1-210) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot: 1/500 - 1/3000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 210 of Human DR3
Specificity	This antibody reacts to Tnf Receptor Superfamily, Member 12 (TNFRSF12) (TNFRSF25) at aa 1-210.
Formulation	0.1 M Tris-glycine, pH 7.0 containing 10% Glycerol and 0.01% Thimerosal State: Aff - Purified State: Liquid purfied Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody (in aliqouts) at -20°C. Avoid repeated freezing and thawing.
Gene Name	tumor necrosis factor receptor superfamily member 25
Database Link	Entrez Gene 8718 Human UniProt ID Q93038
Background	Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kB activation.
Synonyms	APO3, DDR3, TNFRSF12, WSL, WSL1, Apo-3, AIR, Death receptor 3, LARD, Protein WSL, Protein WSL-1
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction

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