GRIA1 pSer836 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1:500 - 1:1000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide sequence around phosphorylation site of serine 836 derived from Human GluR1
Specificity	This antibody detects endogenous level of GluR1 only when phosphorylated at serine 836.
Formulation	Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Affinity-chromatography using epitope-specific peptide
Conjugation	Unconjugated
Storage Condition	Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Gene Name	glutamate ionotropic receptor AMPA type subunit 1
Database Link	Entrez Gene 14799 MouseEntrez Gene 50592 RatEntrez Gene 2890 Human UniProt ID P42261
Background	Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms	GluR-1, GRIA1, GLUH1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA1
Note	Molecular weight: 110 kDa
Reference Data
Protein Families	Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
Protein Pathways	Amyotrophic lateral sclerosis (ALS), Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction

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