PKM2 (PKM) (36-40) Rabbit Polyclonal Antibody
CAT#: AP26067PU-S
PKM2 (PKM) (36-40) rabbit polyclonal antibody, Aff - Purified
Size: 100 ul
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CNY 1,400.00
货期*
2周
规格
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | Western blot: 1:1000. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Peptide sequence around aa. 36~40 |
Specificity | This antibody detects endogenous levels of total PKM2 protein. |
Formulation | Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Affinity-chromatography using epitope-specific peptide |
Conjugation | Unconjugated |
Storage Condition | Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing. |
Gene Name | pyruvate kinase, muscle |
Database Link | |
Background | Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. |
Synonyms | PK2, PK3, PKM, CTHBP, M2-PK, THBP1, OIP3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase M1/M2, Pyruvate kinase muscle |
Note | Molecular weight: 60 kDa |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Glycolysis / Gluconeogenesis, Metabolic pathways, Purine metabolism, Pyruvate metabolism, Type II diabetes mellitus |
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