Tnfrsf1b Rabbit Polyclonal Antibody

CAT#: AP26366PU-N

Tnfrsf1b rabbit polyclonal antibody, Purified



Need it in bulk or conjugated?
Get a free quote

CNY 7,031.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications ELISA, FN, IP, WB
Recommend Dilution Flow cytometry: The typical starting working dilution is 1:50.
Immunoassay.
Immunoprecipitation.
Western blot: The typical starting working dilution is 1:50.
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Specificity
The antibody recognizes the extracellular part of the mouse Tumor Necrosis Factor Receptor type 2 (TNF-RII) of the membrane-bound as well as the soluble receptor. it cross reacts with mouse TNF-RI (problematic in case of TNF-RII knockout studies and when used in high concentrations in functional studies). Shows minimal cross reactivity with mouse TNF-alpha.
Formulation PBS
State: Purified
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 0.1% bovine serum albumin
Concentration lot specific
Purification Protein A
Conjugation Unconjugated
Storage Condition Store at 2 - 8 °C.
Gene Name tumor necrosis factor receptor superfamily, member 1b
Background TNF-RII (~75-80 kDa) is present on most cell types and is considered to play a prominent role in cell stimulation by TNF-alpha. TNF-alpha activates inflammatory responses, induces apoptosis, regulates cellular proliferation, and may even promote cancer progression. The effects of TNF-alpha are mediated by TNF-RI and TNF-RII, which have both distinct and overlapping downstream signaling cascades. Induction of cytotoxicity and other functions are mediated largely via TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is efficiently activated only by the membrane bound form of TNF-alpha. Binding of the inherently trimeric TNF-alpha to TNFR1 and TNFR2 induces receptor trimerization and recruitment of several signaling proteins to the cytoplasmic domains of the receptors. Occupancy of TNFR2 results in direct recruitment of TNF Receptor Associated Factor 2 (TRAF2), which in turn recruits TRAF1.
Synonyms Tumor necrosis factor receptor 2, p80 TNF-alpha receptor, TNFRSF1B, TNFBR, TNF-R2
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...