TJP1 (alpha plus) Rabbit Polyclonal Antibody
CAT#: AP26402PU-N
TJP1 (alpha plus) rabbit polyclonal antibody, Purified
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CNY 6,281.00
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Specifications
Product Data | |
Applications | FC, IF, IHC, WB |
Recommend Dilution | Immunohistochemistry on Frozen Sections: The typical starting working dilution is 1/50. Immunohistochemistry on Paraffin Sections: The typical starting working dilution is 1/50. Flow Cytometry. Immunofluorescence: The typical starting working dilution is 1/50. Western blot: The typical starting working dilution is 1/50. |
Reactivity | Canine, Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Amino acids 886-995 of Human ZO-1 |
Specificity | This antibody recognizes specifically ZO-1 alpha-plus. |
Formulation | PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide |
Concentration | lot specific |
Purification | Protein A Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C. |
Gene Name | tight junction protein 1 |
Database Link | |
Background | Zona occludens 1 (ZO-1) is an ~220 kDa tight junction protein belonging to the membrane-associated guanlyate kinase (MAGUK) family. Members of this family are involved in epithelial and endothelial intercellular junctions. They each contain at least one PSD95/Dlg/ZO-1 (PDZ) domain, a Src homology 3 (SH3) domain, and an enzymatically inactive guanylate kinase domain. PDZ domains are 90-amino acid protein-protein binding domains that recognize at least a 3-residue peptide motif in the COOH termini of their binding partners. PDZ domain-containing proteins, like ZO-1, typically act as scaffolding proteins that organize membrane receptors and cytosolic proteins into multimeric signaling complexes often at the sites of cell-cell contact. The effectiveness and stability of the epithelial barrier depends on a complex of proteins composing different intercellular junctions, which include tight junctions, adherens junctions, and desmosomes. |
Synonyms | Zo1, Tjp1 |
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