Gap43 (C-term) Chicken Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	Western blot: 1/2000. Immunoflourescence: 1/500.
Reactivity	Human, Mouse, Rat
Host	Chicken
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to amino acid residues from the C-terminal region of the rat GAP43 sequence
Specificity	This antibody detects GAP43.
Formulation	PBS State: Ig Fraction State: Liquid IgY fraction Preservative: 10 mM NaN3
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	growth associated protein 43
Database Link	Entrez Gene 29423 Rat UniProt ID P07936
Background	GAP-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration (Benowitz and Routtenberg, 1997). There is also evidence from knockout animals that GAP-43 serves to amplify pathfinding signals from the growth cone (Strittmatter et al., 1995). GAP-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser 41 by protein kinase C modulates the interaction of GAP-43 with actin (He et al., 1997) and may also affect neurotransmitter release during forms of plasticity like LTP (Hulo et al., 2002).
Synonyms	Neuromodulin
Reference Data

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