KCNN4 (227-239) Goat Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 3.75 - 7.5 µg/ml.
Reactivity	Human, Bovine, Canine, Rabbit
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from positions 227-239 of human KCNN4 (NP_002241.1)
Specificity	This antibody reacts to Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (Kcnn4) at aa 227-239.
Formulation	Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative State: Aff - Purified State: Liquid purfied Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	potassium calcium-activated channel subfamily N member 4
Database Link	Entrez Gene 3783 Human UniProt ID O15554
Background	Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
Synonyms	KCNN4, IK1, IKCA1, KCA4, SK4, KCa3.1, Putative Gardos channel
Note	The Kcnn4 synonym, IK1, also is used to describe the cardiac inward rectifier current.
Reference Data
Protein Families	Druggable Genome, Ion Channels: Potassium, Transmembrane

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