Caveolin 1 (CAV1) (C-term) Rabbit Polyclonal Antibody
CAT#: AP31042PU-N
Caveolin 1 (CAV1) (C-term) rabbit polyclonal antibody, Purified
Need it in bulk or conjugated?
Get a free quote
CNY 6,314.00
货期*
6周
规格
Specifications
Product Data | |
Applications | IHC |
Recommend Dilution | Immunohistochemistry on Paraffin Sections: 1/50. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A synthetic peptide from C-terminal domain of human caveolin-1 |
Specificity | This antibody reacts to the C-term of Caveolin-1 (CAV1). |
Formulation | 10 mM PBS, pH 7.4 containing BSA as stabilizer and 0,09% sodium azide as preservative State: Purified State: Liquid purfied Ig fraction |
Purification | Immunoaffinity Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! |
Gene Name | caveolin 1 |
Database Link | |
Background | Caveolae (also known as plasmalemmal vesicles) are 50-100 nm flask- shaped membranes that represent a subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules (including LDL( across capillary endothelial cells, uptake of small molecules via potocytosis and the compartmentalization of certain signaling molecules including G protein-coupled receptors. Three proteins, caveolin-1, caveolin-2 and caveolin-3 have been identified as principle components of caveolae. Caveolin 1 (CAV1) is the main component of the caveolae plasma membranes found in most cell types. Caveolin 1 functions as a membrane adaptor to link integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. CAV1 may also be a tumor suppressor gene and a negative regulator of the Ras-p42/44 MAP kinase cascade. |
Synonyms | CAV1 |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Focal adhesion, Viral myocarditis |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
其它Caveolin 1产品
Customer
Reviews
Loading...