GRIA1 (264-277) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Peptide ELISA: Detection Limit: 1/16000. Western Blot: 0.1-0.3 µg/ml. Approx 100kDa band observed in Human, Mouse and Rat Brain (Cerebellum) lysates.
Reactivity	Human, Mouse, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence from the internal region of the protein sequence according to NP_000818.2; NP_001107655.1.
Specificity	This antibody is expected to recognize both reported isoforms (NP_000818.2 and NP_001107655.1).
Formulation	Tris saline, pH~7.3 with 0.02% Sodium Azide and 0.5% BSA State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	glutamate ionotropic receptor AMPA type subunit 1
Database Link	Entrez Gene 14799 MouseEntrez Gene 50592 RatEntrez Gene 2890 Human UniProt ID P42261
Background	Glutamate dehydrogenase has a central role in nitrogen metabolism in plants and animals. Glutamate dehydrogenase is found in all organisms and catalyzes the oxidative deamination of 1-glutamate to 2-oxoglutarate. Glutamate, the main substrate of Glutamate dehydrogenase, is present in brain in concentrations higher than in other organs. In nervous tissue, Glutamate dehydrogenase appears to function in both the synthesis and the catabolism of glutamate and perhaps in ammonia detoxification.
Synonyms	GluR-1, GRIA1, GLUH1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA1
Note	Calculated Molecular Weight: 102kDa (NP_000818.2).
Reference Data
Protein Families	Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
Protein Pathways	Amyotrophic lateral sclerosis (ALS), Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction

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