MMP11 (61-110) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA: 1/20000. Immunofluorescence: 1/100 - 1/500. Immunohistochemistry on Paraffin Sections: 1/100. Western Blot: 1/500 - 1/1000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide from Human MMP-11 (aa61-110)
Specificity	This antibody detects endogenous levels of total MMP-11 protein (aa61-110).
Formulation	PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM Sodium Chloride, 0.02% Sodium Azide and 50% Glycerol State: Aff - Purified State: Liquid purified IgG fraction
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	matrix metallopeptidase 11
Database Link	Entrez Gene 17385 MouseEntrez Gene 25481 RatEntrez Gene 4320 Human UniProt ID P24347
Background	MMP11, also known as stromelysin 3, is overexpressed in the stromal cells of invasive breast carcinomas but not in the stromal cells surrounding benign breast fibroadenomas. MMP11 is secreted in its proenzyme from and the zymogen has a mass of 64 kDa. The enzyme is rapidly activated to a 58 kDa form, a 45-47 kDa size, then to a 28 kDa final active form. MMP11 is not constitutively produced by most cell types. It has been found in lung fibroblasts and gingival fibroblasts when stimulated with EGF, as well as breast tumor and osteocarcinoma cell lines.
Synonyms	MMP11, Stromelysin-3, SL-3, ST3, STMY3, Matrix metalloproteinase-11
Reference Data
Protein Families	Druggable Genome, Protease

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