DARC (ACKR1) (1-50) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC
Recommend Dilution	ELISA: 1/40000. Immunofluorescence: 1/100 - 1/500. Immunohistochemistry on Paraffin Sections: 1/200.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide from human DARC (aa 1-50)
Specificity	This antibody detects endogenous levels of total CD234 protein.
Formulation	PBS (without Mg2+, Ca2+), pH 7.4, 150 mM Sodium Chloride, 0.02% Sodium Azide and 50% Glycerol State: Aff - Purified State: Liquid purified Ig fraction
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody (in aliquots) at -20°C or lower. Avoid freeze-thaw cycles.
Gene Name	atypical chemokine receptor 1 (Duffy blood group)
Database Link	Entrez Gene 2532 Human UniProt ID Q16570
Background	Duffy blood group antigens, part of the Chemokine Receptor family, appear to be multimeric erythrocyte-membrane protein receptors composed of different subunits. A glycoprotein, GPD, is the major subunit of the protein complex. Other components include the Rh, PGM1, Fy, and PEPC proteins. Duffy antigen is expressed by red blood cells, by postcapillary venule endothelium throughout the body, except in the liver, and by Purkinje cells of the cerebellum. Duffy negativity (lack of Duffy expression in bone marrow) has been linked to protection against malaria. In erythrocytes, the chemokines interleukin-8 and melanoma growth stimulatory activity (MGSA) activate Duffy antigen.
Synonyms	Duffy antigen/chemokine receptor, Fy glycoprotein, GpFy, Glycoprotein D, FY, GPD
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane

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