HLA-DQA2 Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	Peptide ELISA: Detection Limit: 1/16000. Western Blot: 0.1-0.3 µg/ml. Approx 26kDa band observed in Human Bone Marrow lysates. Immunohistochemistry on Paraffin Sections: 3.75µg/ml.
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence from the internal region of the protein sequence according to NP_064440.1.
Specificity	Recognizes HLA-DQA2
Formulation	Tris saline, pH~7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	major histocompatibility complex, class II, DQ alpha 2
Database Link	Entrez Gene 3118 Human UniProt ID P01906
Background	HLADQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). HLADQA2 forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site.
Synonyms	HLA-DXA, DX alpha chain, HLA-DQA1, MHC class II DQA2
Note	Calculated Molecular Weight: 28.0kDa (NP_064440.1)
Reference Data

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