Choline Acetyltransferase (CHAT) Chicken Polyclonal Antibody

CAT#: AP31801PU-N

Choline Acetyltransferase (CHAT) chicken polyclonal antibody, Aff - Purified



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CNY 7,688.00


货期*
5周

规格
    • 100 ug

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Specifications

Product Data
Applications IF, IHC
Recommend Dilution Immunocytochemistry.
Immunohistochemistry.
Recommended Dilutions: 1/1000-1/2000 for Immunohistochemstry and Immunocytochemistry using 2% paraformaldehyde-fixed tissues or cells.
Quality Control: The antibody was analyzed by Immunohistochemistry (at 1/2000) using Fluorescein-labeled Goat anti-Chicken IgY (Cat.-No AP31795FC-N, 1/500 dilution) as the secondary reagent.
Reactivity Human, Mouse
Host Chicken
Clonality Polyclonal
Immunogen Synthetic peptide KLH conjugated corresponding to a region of the Choline Acetyltransferase gene product shared between the Human (P28329) and Mouse (Q03059) sequences.
After repeated injections, immune eggs were collected, the IgY fractions were purified from the yolks and then affinity-purified using a peptide column.
Specificity Recognizes Choline Acetyltransferase (ChAT).
Formulation 10mM PBS, pH 7.2 containing 0.02% Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified (filter sterilized) IgY fraction.
Concentration lot specific
Purification Affinity Chromatography using a peptide column.
Conjugation Unconjugated
Storage Condition Store undiluted in the dark at 2-8°C.
Gene Name choline O-acetyltransferase
Background Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).
Synonyms Choline O-acetyltransferase, Choline acetylase, CHOACTase, ChAT, EC=2.3.1.6
Reference Data
Protein Families Druggable Genome
Protein Pathways Glycerophospholipid metabolism
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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