Cadherin like 23 (CDH23) (61-110) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC
Recommend Dilution	ELISA: 1/10000. Immunofluorescence: 1/100 - 1/500. Immunohistochemistry on Paraffin Sections.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	CDH23 / Cadherin 23 antibody was raised against synthetic peptide from human CDH23 (aa61-110). Epitope: aa61-110.
Specificity	This antibody detects endogenous levels of total CDH23 protein.
Formulation	PBS (without Mg2+, Ca2+), pH 7.4, 150 mM Sodium Chloride, 50% Glycerol State: Aff - Purified State: Liquid purified IgG fraction Preservative: 0.02% Sodium Azide
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cadherin-related 23
Database Link	Entrez Gene 64072 Human UniProt ID Q9H251
Background	Cadherin like 23 (or Cadherin 23) is, like other members of the cadherin family, a calcium-dependent cell adhesion glycoprotein that preferentially interacts with itself in connecting cells. It is a single pass type I membrane protein that contains 27 cadherin domains. Cadherin like 23 is expressed in the neurosensory epithelium, where it is thought to be involved in stereocilia organisation and hair bundle formation. Defects in the gene encoding Cadherin like 23 are a cause of Usher syndrome, which is characterised by profound congenital sensorineural deafness and eventual blindness. Mutations in this gene are also a cause of non-syndromic sensorineural deafness autosomal recessive type 12 (DFNB12). Cadherin like 23 has also been associated with age-related hearing loss.
Synonyms	CDH23, KIAA1774, KIAA1812
Reference Data

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