Protein downstream neighbor of Son (DONSON) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/200-1/5000. Immunohistochemistry: 1/100-1/2000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from C terminal part of Human DONSON protein.
Specificity	This antibody recognizes DONSON.
Formulation	0.1M Tris, 0.1M Glycine, 2% Sucrose State: Purified State: Lyophilized powder Preservative: None
Reconstitution Method	Restore in distilled water
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	downstream neighbor of SON
Database Link	Entrez Gene 29980 Human UniProt ID Q9NYP3
Background	The smallest of the human chromosomes, 21 makes up about 1.5% of the human genome. Chromosome 21 contains nearly 300 genes and 47 million base pairs. Down syndrome, also known as trisomy 21, is the disease most commonly associated with chromosome 21. The gene encoding DONSON (downstream neighbor of Son) is located on the long arm of chromosome 21 within 65 base pairs of the 3’ end of the SON gene, which encodes a nuclear protein that represses Hep B virus promoter activity and transcription of HBV genes. DONSON is a 566 amino acid nuclear protein that has the ability to be phosphorylated and is possibly required for DNA amplification in the ovary. Also, it is probable that DONSON is needed for cell proliferation during development. There are three isoforms of DONSON which exist as a result of alternative splicing events.
Synonyms	C21orf60
Reference Data

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