Gelsolin (GSN) (Isoform a) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Peptide ELISA: 1/64000 (Detection limit). Western Blot: 1-3 µg/ml. Detects a band of Approx 100kDa in Human Colon, Duodenum, Heart and Skeletal Muscle lysates.
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic Peptide (PQGRVPEARPNS-C) from the N-Terminus of the protein sequence according to NP_000168.1; NP_937895.1; NP_001121138.1.
Specificity	This antibody is expected to recognize Isoform a (NP_000168.1) only.
Formulation	Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	85.7 kDa (NP_000168.1).
Gene Name	gelsolin
Database Link	Entrez Gene 2934 Human UniProt ID P06396
Background	Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells. Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
Synonyms	Brevin, AGEL, GSN
Reference Data

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