PDE4 (PDE4B) (C-term) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Peptide ELISA: 1/32000 (Detection limit).  Western blot: 1-3 µg/ml. Approx 98kDa band observed in Human Uterus lysates. The observed molecular weight corresponds to earlier findings in literature with different antibodies (Méhats et al, Endocrinology. 1999 Jul;140(7):3228-37. PMID: 10385419).
Reactivity	Human, Mouse
Host	Goat
Clonality	Polyclonal
Immunogen	syntehtic peptide (C-IDIATEDKSPVDT) from the C Terminus of the protein sequence according to NP_002591.2; NP_001032416.1; NP_001032417.1.
Specificity	This antibody is expected to recognize all reported isoforms (NP_002591.2, NP_001032416.1, NP_001032417.1).
Formulation	Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	83.3 kDa (NP_002591.2).
Gene Name	phosphodiesterase 4B
Database Link	Entrez Gene 5142 Human UniProt ID Q07343
Background	Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE4 enzyme belongs to a family of cAMP-dependent PDEs that provide the major means of inactivating the key intracellular second messenger, cAMP.Four genes (4A, 4B, 4C, and 4D) encode around 20 distinct isoform members of the PDE4 family. Each isoform is characterized by a unique N-terminal region.
Synonyms	PDE4B, DPDE4, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, EC=3.1.4.17, PDE32
Reference Data

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