thrb Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Peptide ELISA: 1/32000 (Detection Limit). Western blot: 2-5 µg/ml. Approx 50kDa band observed in Zebrafish adult Heart lysates (calculated MW of 44.3kDa according to NP_571415.1).
Reactivity	Zebrafish
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence from the internal region of the protein sequence according to NP_571415.1.
Specificity	This antibody recognizes Thrb (Zebrafish) and is not expected to cross-react to THRA.
Formulation	Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	thyroid hormone receptor beta
Database Link	Entrez Gene 30607 Zebrafish UniProt ID Q9PVE4
Background	Thyroid hormone receptors (TRs) are ligand dependent members of the steroid/retinoic acid superfamily of transcription factors. The two genes encoding TRs identified to date, TRalpha and TRBeta, have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with half site binding motifs in the orientation of palindromes, direct repeats, or inverted palindromes. The affinities of binding are both variable and influenced differentially by 3,5,3-triiodo-L-thyronine (T-3).
Synonyms	Thyroid hormone receptor beta, THR1, NR1A2
Reference Data

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