L-Kynurenic Acid Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	ELISA: 1/8000.
Host	Rabbit
Clonality	Polyclonal
Immunogen	L-Kynurenic Acid KLH-conjugated
Specificity	This antibody detects L-Kynurenic acid. Cross reactivity obtained with 3-Hydroxy-Kynurenine, was less than 0.2%. Thre was no no cross reactivity obtained with Indole Serotonin, or Quinoline.
Formulation	State: Serum State: Lyophilized Serum
Reconstitution Method	Restore in aqua bidest to initial volume
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Background	Kynurenic acid (KYNA or KYN) is a product of the normal metabolism of amino acid L-tryptophan. It has been shown that kynurenic acid possesses neuroactive activity. It acts as an antiexcitotoxic and anticonvulsant, most likely through acting as an antagonist at excitatory amino acid receptors. Because of this activity, it may influence important neurophysiological and neuropathological processes. As a result, kynurenic acid has been considered for use in therapy in certain neurobiological disorders. Conversely, increased levels of kynurenic acid have also been linked to certain pathological conditions. Kynurenic acid was discovered in 1853 by the German chemist Justus von Liebig in dog urine, which it was apparently named after. (1) It is formed from L-kynurenine in a reaction catalyzed by the enzyme kynurenine—oxoglutarate transaminase.
Synonyms	kynuronic acid, quinurenic acid, transtorine, KynA, 4-hydroxyquinoline-2-carboxylic acid, kinurenic acid
Note	CAS numbe: 492-27-3 Molecular formula: C10H7NO3 Molar mass: 189.168 g/mol Melting point: 282.5°C
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.