ARMETL1 (CDNF) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA: 1/5000-1/10000.   Western Blot: 1/5000-1/10000.  Immunofluorescence: 1/500-1/3000. Immunohistochemistry on Paraffin Sections: 1/100-1/200. Formalin-fixed, paraffin-embedded tissues requires antigen retrieval.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant Human CDNF produced using CHO-based.  Antigen is purified from cell culture supernatant.
Specificity	Recognizes Human and Mouse CDNF. Other species not tested.
Formulation	50% Saturated Ammonium Sulphate in PBS pH 7.4 State: Aff - Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Upon receipt, store at 2-8°C. As product is (NH4)2SO4 precipitate, mix well by pipetting or vortexing prior use.
Gene Name	cerebral dopamine neurotrophic factor
Database Link	Entrez Gene 441549 Human UniProt ID Q49AH0
Background	CDNF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007; Voutilainen et al., 2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine neurons in rodent models of Parkinson’s disease. When administered after 6-OHDA or MPTP –lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta.
Synonyms	ARMET-like protein 1, ARMETL1
Reference Data

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