Telomerase reverse transcriptase (TERT) (627-656) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IF, IHC, WB
Recommend Dilution	Flow Cytometry: 1/10 - 1/50. Immunofluorescence: 1/10 - 1/50. Immunohistochemistry on Paraffin Sections: 1/100. Western Blot: 1/1000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide selected from the Center region of Human TERT. Epitope: 627-656
Specificity	This antibody detects Human TERT at center. Other species not tested.
Formulation	PBS State: Purified State: Liquid Ig fraction Preservative: 0.09% (W/V) Sodium Azide
Purification	Ammonium Sulfate Precipitation
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	126997 Da
Gene Name	telomerase reverse transcriptase
Database Link	Entrez Gene 7015 Human UniProt ID O14746
Background	Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.
Synonyms	Telomerase reverse transcriptase, HEST2, EST2, TCS1, TRT
Reference Data

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