14-3-3 sigma (SFN) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IF, IHC, WB
Recommend Dilution	Western blotting: 1/1000. Immunohistochemistry on Paraffin Sections: 1/10-1/50. Flow Cytometry: 1/10-1/50. Immunofluorescence: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 222-248 amino acids from the C-terminal region of Human SFN.
Specificity	This antibody recognizes Human SFN (C-term). Other species not tested.
Formulation	PBS State: Purified State: Liquid purified Ig fractioon Preservative: 0.09% (W/V) Sodium Azide
Concentration	lot specific
Purification	Protein A column, followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	27774 Da
Gene Name	stratifin
Database Link	Entrez Gene 2810 Human UniProt ID P31947
Background	Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axolly transported to the nerve termils. They are also present, at lower levels, in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of sigl transduction pathways, including those involved in cell cycle regulation and cell survival. Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in sigling pathways mediated by serine/threonine protein kises. Evidence indicates 14-3-3 is required for Raf 1 kise activity and phosphorylation among many other functions.
Synonyms	Stratifin, HME1
Reference Data

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