AKR1C2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 295-323 amino acids from the C-terminal region of human AKR1C2
Formulation	PBS containing 0.09% (W/V) sodium azide as preservative
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Predicted Protein Size	36.6 kDa
Gene Name	aldo-keto reductase family 1, member C2
Database Link	NP_001345 Entrez Gene 1646 Human UniProt ID P52895
Background	This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Synonyms	3-alpha-HSD3; AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2; DDH2; FLJ53800; HAKRD; HBAB; MCDR2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolism of xenobiotics by cytochrome P450

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