AMCase (CHIA) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, WB
Recommend Dilution	Peptide ELISA: 1/1000. Western blot: 1/100 - 1/500. Flow cytometric: 1/10 - /50.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 20-47 amino acids from the N-terminal region of human CHIA.
Specificity	This antibody reacts to CHIA.
Formulation	PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% (W/V) sodium azide
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	52271 Da
Gene Name	chitinase, acidic
Database Link	Entrez Gene 27159 Human UniProt ID Q9BZP6
Background	CHIA degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. There are 3 named isoforms produced by alternative splicing. CHIA is induced via a T helper-2 (Th2)-specific, interleukin-13-mediated pathway in epithelial cells and macrophages. CHIA may be an important mediator of IL13-induced responses in Th2-dominated disorders such as asthma. CHIA hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.
Synonyms	Acidic mammalian chitinase, CHIA, TSA1902
Reference Data
Protein Families	Secreted Protein
Protein Pathways	Amino sugar and nucleotide sugar metabolism

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