GPR17 (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	This antibody is suitable for flow cytometry, immunohistochemistry on paraffin sections and Western blotting. The suggested dilution is: Flow cytometry:  1/10-1/50. Immunohistochemistry on paraffin sections:  1/50-1/100. Western blotting:  1/100-1/500.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide - KLH conjugated - corresponding to the central region (between 237-266aa) of human GPR17.
Specificity	This antibody detects human GPR17.
Formulation	PBS with 0.09% (W/V) Sodium Azide. State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Purified through a protein A column; followed by peptide affinity purification.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	G protein-coupled receptor 17
Database Link	Entrez Gene 2840 Human UniProt ID Q13304
Background	Members of the G protein coupled receptor (GPCR) superfamily contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The organization of the GPR17 gene differs from that of many other GPCRs in that the open reading frame is distributed on 2 exons; an additional exon contains the 5 prime untranslated region. Human GPR17 is expressed as 2.3 and 6.3 kb mRNAs exclusively in brain. The 2 transcripts appear to represent alternatively polyadenylated variants. Based on protein sequence homology and the conservation of certain key residues, GPR17 appears to be closely related to the P2Y family of GPCRs. There are two nemed isoforms.
Synonyms	UDP/CysLT receptor, G-protein coupled receptor 17, P2Y-like receptor, R12
Note	Molecular Weight: 40989 Da
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane

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