Glutathione Reductase (GSR) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IF, IHC, WB
Recommend Dilution	ELISA: 1/1000. Western Blot: 1/100-1/500.   Flow Cytometry: 1/10-1/50.  Immunofluoresecnce: 1/10-1/50.  Immunohistochemistry on Paraffin Sections: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 387-416 amino acids from the C-terminal region of human Glutathione reductase.
Specificity	This antibody recognizes Human Glutathione reductase (C-term).
Formulation	PBS containing 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A column, followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	glutathione reductase
Database Link	Entrez Gene 2936 Human UniProt ID P00390
Background	This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
Synonyms	GRase, GR, GSR, GLUR, GRD1
Note	Molecular Weight: 56257 Da
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Glutathione metabolism

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