IGSF8 (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry (Paraffin sections):  1/10-1/50 Western blotting:  1/100-1/500 ELISA:  1/1000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide (233-262 aa) - KLH conjugated - corresponding to internal domain of human IGSF8.
Specificity	This antibody detects IGSF8 (Center).
Formulation	PBS with 0.09% (W/V) Sodium Azide. State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Purified through a protein A column; followed by peptide affinity purification.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	immunoglobulin superfamily member 8
Database Link	Entrez Gene 140559 MouseEntrez Gene 93185 Human UniProt ID Q969P0
Background	GSF8/PGRL/EWI-2 is a membrane protein that contains 4 Ig domains and forms highly proximal, specific and stoichiometric complexes with both CD9 and CD81 a tetraspanin. Tetraspanins and their molecular partners from primary complexes that then undergo tetraspanin-tetraspanin interactions to form a network of molecular interactions call a tetraspanin web. IGSF8 then may play a key role in diverse functions ascribed to CD81 and CD9 including oocyte fertilization or hepatitis C virus function, regulation of proliferation and differentiation of keratinocytes. It may also be a negative regulator of cell motility and suppress T-cell mobility coordinately with CD81.
Synonyms	CD81 partner 3, LIR-D1, CD81P3, EWI2, KCT4
Note	Molecular Weight: 65034 Da
Reference Data
Protein Families	Transmembrane

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