MYH (MUTYH) (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IF, WB
Recommend Dilution	Flow cytometry:  1/10-1/50. Immunofluorescence:  1/10-1/50. Western blot:  1/50-1/100. Enzyme immunoassay:  1/1000.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide - KLH conjugated - corresponding to the central region (between 352-381aa) of human MUTYH.
Specificity	This antibody recognizes MUTYH.
Formulation	PBS with 0.09% (W/V) Sodium azide State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	mutY DNA glycosylase
Database Link	Entrez Gene 70603 MouseEntrez Gene 4595 Human UniProt ID Q9UIF7
Background	MYH is the eukaryotic homolog to the E. coli protein MutY. It was first identified in HeLa cells and nicks DNA replication errors, specifically A/G mismatches. MYH is involved in oxidative DNA damage repair and initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. It possesses both adenine and 2-OH-A DNA glycosylase activities.
Synonyms	MYH, MutY homolog
Note	Molecular Weight: 60069 Da
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Base excision repair

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