Mu Opioid Receptor (OPRM1) (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	Western Blot: 1/1000. Flow Cytometry: 1/10-1/50. Immunohistochemistry on Paraffin Sections: 1/10-1/50.
Reactivity	Human, Monkey, Mouse, Porcine, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 161-187 amino acids from the Center region of human OPRM1
Specificity	This antibody recognizes Human and Mouse OPRM1 (Center).
Formulation	PBS containing 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A column, followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	opioid receptor mu 1
Database Link	Entrez Gene 18390 MouseEntrez Gene 25601 RatEntrez Gene 574141 MonkeyEntrez Gene 4988 Human UniProt ID P35372
Background	OPRM1 is the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin (see POMC, MIM 176830) and the enkephalins (see PENK, MIM 131330). The OPRM1 receptor is a membrane of the G protein-coupled receptor family (Bond et al., 1998 [PubMed 9689128]). There are at least 3 types of opioid receptors, mu, kappa (OPRK1; MIM 165196), and delta, each with a distinct pharmacologic profile.
Synonyms	Mu-type opioid receptor, MOR1
Note	Molecular Weight: 44779 Da
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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